Differential diagnosis of AIP attacks

Common clinical conditions mimicked by an acute porphyric attack1

Dismetabolic/​disendocrine conditions

Acute hypoadrenalism (Addisonian crisis)

Acute hypoparathyroidism and hypocalcemic crisis

  • Pheocromocytoma
Neurolopsychiatric conditions

Guillain‑BarrĂ© syndrome

Emicrania

Acute psychotic attack

Delirium

Acute panic attack

Epilepsy

  • Acute myopathies
Cardiovascular conditions

Hypertensive crisis

  • Tachyarrhythmia
Hematological conditions

Acute hemolytic crisis

  • Acute drepanocytic crisis
Gastroenterological conditions

Acute gastroenteritis with vomiting

Dismetabolic/​disendocrine conditions

Acute hypoadrenalism (Addisonian crisis)

Acute hypoparathyroidism and hypocalcemic crisis

  • Pheocromocytoma
Neurolopsychiatric conditions

Guillain‑BarrĂ© syndrome

Emicrania

Acute psychotic attack

Delirium

Acute panic attack

Epilepsy

  • Acute myopathies
Cardiovascular conditions

Hypertensive crisis

  • Tachyarrhythmia
Hematological conditions

Acute hemolytic crisis

  • Acute drepanocytic crisis
Gastroenterological conditions

Acute gastroenteritis with vomiting

Reference:

Ventura P, et al, A challenging diagnosis for potential fatal diseases: Recommendations for diagnosing acute porphyrias. Eur J Intern Med 2014, https://dx.doi.org/10.1016/j.ejim.2014.03.011