Signs and symptoms during acute attacks of AIP1,†

Percentage of patients. Pain abdomen (74%). Nausea/vomiting (73%). Weakness (63%). Constipation (60%). Anxiety/depression (55%). Palpitations (50%). High BP (40%). Diarrhea (29%). Sun sensitivity (20%). Fever (18%). Seizures (9%). Adapted from Bonkovsky 2014.

Understanding AIP / What is AIP? / Clinical Features / Signs and Symptoms / Prevalence of Symptoms / AIP Triggers / Long‑term Complications

† Between September 2010 and December 2012, 108 subjects with acute porphyrias (90 acute intermittent porphyrias, 9 hereditary coproporphyrias, 9 variegate porphyrias) were enrolled into an observational study. Genetic testing was performed at a central genetic testing laboratory and clinical information entered into a central database. Selected features were compared with data for adults in the US.

Reference:

Bonkovsky HL, Maddukuri VC, Yazici C, Anderson KE, Bissell M, Bloomer JR, et al. Acute porphyrias in the USA: features of 108 subjects from porphyrias consortium. Am J Med 2014;127:1233‑1241.