Signs and symptoms during acute attacks of AIP1,†

Percentage of patients. Pain abdomen (74%). Nausea/vomiting (73%). Weakness (63%). Constipation (60%). Anxiety/depression (55%). Palpitations (50%). High BP (40%). Diarrhea (29%). Sun sensitivity (20%). Fever (18%). Seizures (9%). Adapted from Bonkovsky 2014.

† Between September 2010 and December 2012, 108 subjects with acute porphyrias (90 acute intermittent porphyrias, 9 hereditary coproporphyrias, 9 variegate porphyrias) were enrolled into an observational study. Genetic testing was performed at a central genetic testing laboratory and clinical information entered into a central database. Selected features were compared with data for adults in the US.


Bonkovsky HL, Maddukuri VC, Yazici C, Anderson KE, Bissell M, Bloomer JR, et al. Acute porphyrias in the USA: features of 108 subjects from porphyrias consortium. Am J Med 2014;127:1233‑1241.