Acute Intermittent Porphyria (AIP)

Porphyrias are inborn errors of metabolism that cause deficient activity within the eight‑step heme synthetic pathway.¹

The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms.¹

• δ‑aminolevulinate dehydratase deficiency porphyria (a very rare autosomal recessive disorder)
• Acute intermittent porphyria (autosomal dominant)
• Hereditary coproporphyria (autosomal dominant)
• Variegate porphyria (autosomal dominant)

Their diagnoses are often missed or delayed because the clinical symptoms mimic other more common disorders.¹