AIP clinical features overview

Symptomatic attacks occur primarily in females between 14 and 45 years of age.1 The following are some of the clinical features of AIP:2

  • Acute attacks almost always start with severe pain in the abdomen but sometimes in the chest, back, or thighs, and are often accompanied by nausea, vomiting, and constipation
  • Heart rate and blood pressure are commonly increased
  • Confusion, convulsions, and muscular weakness, due to impairment of the nerves controlling the muscles, may lead to paralysis
  • An acute attack usually lasts for days or weeks
  • Recovery from severe paralysis is generally slow


  1. Wang B, Rudnick S, Cengia B, et al. Acute Hepatic Porphyrias: Review and Recent Progress. Hepatol Commun 2019;3(2):193‑206.
  2. Rare Diseases Clinical Research Network. The Porphyrias Consortium. Disorder Definitions. Accessed January 14, 2020 at​/cms/porphyrias/Healthcare-Professionals/Disorder-Definitions